Dr Vera's Acetyl-L-Carnitine :: Dr Vera's :: Health Supplements / Vitamins Australia :: Online Health Store Australia
Dr Vera's Acetyl-L-Carnitine #1453270969 |
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Dr
Vera's Acetyl-L-Carnitine
Excipients
Glycine, silica colloidal anhydrous, vegetable capsules
Dosage
1-2 capsules per day, or as prescribed
Indications
May be beneficial for conditions associated with:
* Mitochondrial dysfunction and energy production
* Cardiovascular support
* Memory and cognitive function
Interactions
No significant evidence of interactions found.
Contraindications
N/A
Each capsule contains:
Acetyllevocarnitine hydrochloride 500mg
TECHNICAL INFORMATION
Acetyl-L-Carnitine
Acetyl-l-carnitine (ALC) is the 0-acetyl derivative of carnitine found naturally
in the body and in small amounts in some foods. Approximately 7.5% - 10.2% of
the body's total carnitine content is in the form of ALC. The enzyme carnitine
acetyltransferase is responsible for the conversion of carnitine to acetyl-l-carnitine.
There appears to be an age-related decline in carnitine acetyltransferase.
Mitochondrial dysfunction
Acetyl-l-carnitine facilitates mitochondrial beta-oxidation of fatty acids.
Acetyl-l-carnitine acts as a shuttle of long chain fatty acids between the
cytosol and the mitochondria to undergo beta-oxidation.[4] ALC is therefore
essential in energy production and in clearing toxic accumulation of fatty acids
in the mitochondria. Acetyl-l-carnitine supplementation may reverse the
age-related decline in many indices of mitochondrial function and general
metabolic activity.[5]
Considering the role of carnitine in mitochondrial
function, it is not surprising that chronic fatigue patients have low serum
carnitine.[6]
It would appear that wherever mitochondrial energy
production is impaired due to disease, ischaemia or trauma, acetyl-l-carnitine
supplementation is warranted.
Memory and cognitive function
In the brain, acetyl-l-carnitine facilitates the synthesis of the
neurotransmitter acetylcholine. It promotes acetylcholine synthesis and release
and induces choline acetyltransferase activity.[7,8] Conditions such as
Alzheimer's disease and age-related dementia are associated with decreased
levels of acetylcholine.[9] Alzheimer's disease patients also exhibit
significantly decreased levels of carnitine acetyltransferase.[10] This suggests
they may have problems with the production of acetyl-l-carnitine.
Memory and cognitive function
In the brain, acetyl-l-carnitine facilitates the synthesis of the
neurotransmitter acetylcholine. It promotes acetylcholine synthesis and release
and induces choline acetyltransferase activity.[7,8] Conditions such as
Alzheimer's disease and age-related dementia are associated with decreased
levels of acetylcholine.[9] Alzheimer's disease patients also exhibit
significantly decreased levels of carnitine acetyltransferase.[10] This suggests
they may have problems with the production of acetyl-l-carnitine.
ALC retards the natural decline in the number of
NMDA receptors (N-Methyl-D-Aspartate Receptors) that occurs in tandem with the
ageing process.[11,12] NMDA receptor activation is involved in learning, memory
and alertness.[13]
Neurotrophic factors/ neuroprotective
Acetyl-I-carnitine has been shown to prevent some impairments of the aged
central nervous system in animal and patient studies. Animal studies show that
acetyl-l-carnitine may also be able to increase the levels and utilization of
nerve growth factor (NGF) in the CNS of old rats.[8] The stimulation of NGF
levels in the CNS can be attained when ALC is given either for long or short
periods to senescent (ageing) animals of various ages, thus indicating a direct
effect of the substance on the NGF system which is independent of the actual
degenerative stage of the neurons.
Cardiac function
The progressive decline in cardiac function associated with age can be
attributed to changes in mitochondrial fatty acid metabolism. Acetyl-l-carnitine
is able to reverse this age-related decrement in mitochondrial carnitine acetyl-carnitine-exchange
activity by restoring normal cardiolipin content.[14] Cardiolipin is a
phospholipid that concentrates in the inner membranes of the mitochondria. It
facilitates electron transport and energy production, assisting in the
maintenance of optimal heart function.
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