Dr Vera's Cal Citrate MXD #1453271485

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Dr Vera's Cal Citrate MXD

Excipients
Glycine, leucine, silica, vegetable capsules

Dosage
1-2 capsules three times daily, or as prescribed

Indications
May be beneficial when calcium requirements
are increased, during
* Bone growth and development
* Menopause and osteoporosis

Interactions
Iron may compete with calcium for absorption; calcium may
interfere with the absorption of some antibiotic medications.
Calcium supplements should therefore not be taken within two
hours of iron or antibiotic medication.[1,2]

Contraindications
Hyperparathyroidism, hypercalcaemia

Formulations
Total calcium 150mg
Calcium (as citrate) 139.7mg
Calcium (as orotate) 10.34mg

TECHNICAL INFORMATION
Calcium
Calcium is an essential mineral which functions in many
intracellular and extracellular processes. These include bone
and teeth mineralisation, muscle contraction, blood clotting,
nerve conduction, hormone release, blood coagulation, energy
production, immune regulation, intracellular signalling and
regulation of numerous enzymes.[3]

Forms of Calcium
Calcium citrate consists of 21-22% calcium bound to citrate
(citric acid). The superior bioavailability of calcium citrate over
calcium carbonate has been confirmed in several studies.[4-6]
When the effect of calcium carbonate and calcium citrate were
assessed on markers of bone resorption in older postmenopausal
women, calcium citrate was found to decrease these markers
significantly more than calcium carbonate.[7]
Calcium orotate consists of 20.6% calcium bound to
orotic acid (orotate) and is considered a well absorbed
form of calcium.

Bone Growth and Development
Calcium is an essential mineral for the support and maintenance
of bone mineralisation throughout life. There is a striking increase
in the rate of skeletal calcium accumulation from 12 to 18 years of
age. The recommended daily intake for this age group therefore
is significant, at 1300mg.[8] Calcium supplementation in the
presence of vitamin D, effectively strengthens bone mineral
content in childhood while maintaining it in adults [9] and has
been shown to significantly enhance bone growth during
growth spurts in females during puberty.[10]
 

*for further information regarding drug/nutrient interactions contact Dr Vera's on 1800 625 934
References
1. Lim, D., McKay, M., Food-drug interactions. Drug Information Bull, 1995. 15(2).
2. Holt, G., Food & Drug Interactions. 1998, Chicago: Precept Press.
3. Braun, L. and M. Cohen, Herbs & Natural Supplements. An evidence-based guide. 2005: p. 90-91.
4. Harvey, J., M. Zobitz, and P. Pak, Dose dependency of calcium absorption: a comparison of calcium carbonate and cacium citrate. J Bone Miner
Res, 1988. 3(3): p. 253-8.
5. Nicar, M. and C. Pak, Calcium bioavailablity from calcium carbonate and calcium citrate. J Clin Endocrinol Metab, 1985. 61(2): p. 391-3.
6. Harvey, J., et al., Superior calcium absorption from calcium citrate than calcium carbonate using external forearm counting.
J Am Coll Nutr., 1990. 9(6): p. 583-7.
7. Kenny, A., et al., Comparison of the effects of calcium loading with calcium citrate or calcium carbonate on bone turnover in postmenopausal women.
Osteoporos Int., 2004. 15(4): p. 290-4.
8. Nutrient reference Values for Australia and New Zealand; including Recommended Dietary Intakes. Australian Government; Department of Health
and Ageing, 2005.
9. Abrams, S.A., Calcium turnover and nutrition through the life cycle. Proc Nutr Soc., 2001. 60(2): p. 283-9.
10. Matkovic, V., et al., Calcium supplementation and bone mineral density in females from childhood to young adulthood: a randomized controlled trial.
Am J Clin Nutr., 2005. 81(1): p. 175-88.
11. Mirza, F., Prestwood, KM., Bone health and ageing: implications for menopause. Endocrinol Metab. Clin North Am., 2004. 33(4): p. 741-59.
12. Dick, I., Devine, A., Beilby, J., Prince, RL., Effects of endogenous oestrogen on renal calcium and phosphate handling in elderly women. Am J Physiol
Endocrinol. Metab., 2005. 288(2): p. E430-5.
13. Ruml, L.A., et al., The effect of calcium citrate on bone density in the early and mid-postmenopausal period: a randomized placebo-controlled study.
Am J Ther., 1999. 6(6): p. 303-11.
14. Heaney, R.P. and C.M. Weaver, Newer perspectives on calcium nutrition and bone quality. J Am Coll Nutr., 2005. 24(6 Suppl.): p. 574S-81S.
15. Riggs, B.L., et al., Long-term effects of calcium supplementation on serum parathyroid hormone level, bone turnover, and bone loss in elderly women.
J Bone Miner Res., 1998. 13(2): p. 168-74.
16. Dawson, K., Endocrine physiology of electrolyte metabolism. Drugs., 1984. 28(Suppl 1): p. 98-111.
17. Griffith, L., et al., The influence of dietary and nondietary calcium supplementation on blood pressure. An updated meta analysis of randomized
controlled trials. Am J Hypertens., 1999. 12(1): p. 84-92.