Dr Vera's Vitamin D3 :: Dr Vera's :: Health Supplements / Vitamins Australia :: Online Health Store Australia
Dr Vera's Vitamin D3 #1453270973 |
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Dr Vera's Vitamin D3
Excipients
Glycine, silica colloidal anhydrous, vegetable capsules
Dosage
1 capsule per day, or as prescribed
Indications
May be useful in conditions involving:
* Immune dysfunction (e.g., autoimmune disorders)
* Poor bone health (e.g., osteoporosis)
* Parathyroid function
Interactions
May interact with calcium channel blockers.[5]
The following medications may increase the body's vitamin D requirements: [5]
* Anti-convulsants (e.g., phenytoin)
* Glucocorticoids
Contraindications
Hypercalcaemia, hyperparathyroidism
Each capsule contains:
Cholecalciferol (vitamin D3)
25µg
(equiv. Vitamin D3 1000IU)
d-alpha tocopheryl acid succinate (vitamin E)
8.34mg
(equiv. Vitamin E 10IU)
TECHNICAL INFORMATION
Vitamin D3
Vitamin D is a fat soluble vitamin that can be produced (from cholesterol) in
the skin in the presence of ultraviolet radiation. Vitamin D3 (cholecalciferol)
is the active metabolite of vitamin D and some consider it to have the actions
of a hormone rather than a vitamin. Vitamin D3 can act in a wide variety of
tissues including intestine, kidney, bone, muscle, skin and immune cells.
Vitamin D may also interact with vitamin D receptors to influence gene
transcription.[6]
Immune Modulation
Recent evidence has suggested a role for vitamin D in the treatment of disorders
associated with immune dysfunction, in particular autoimmune disorders. [7]
Vitamin D receptors are expressed on certain immune cells and activation of
these receptors may enhance CD4+ and CD25+ suppressor T cells that, in turn, may
inhibit T-helper 1 cell responses, modulating immune responses.[8]
Studies have indicated a protective effect of vitamin D3 on the development of
autoimmune disorders such as multiple sclerosis,[9] inflammatory bowel
disease,[7] and rheumatoid arthritis.[10]
Bone Health
Vitamin D is heavily involved in the body's absorption and utilisation of
calcium making it important for optimal bone health. In a randomised controlled
trial, thirty women (mean age = 78 years; range = 58-88) with a proximal humoral
fracture, osteoporosis or osteopenia, and not taking any drugs related to bone
formation, including calcium or vitamin D supplementation, were randomly
assigned to either oral 800 IU vitamin D3 plus 1 g calcium or placebo. The study
concluded that there was a positive influence of vitamin D3 and calcium over the
first 6 weeks after fracture.
Parathyroid Function
In conjunction with parathyroid hormone, vitamin D3 can stimulate calcium and
phosphorous absorption in the intestines, and reabsorption in the kidneys.[12]
It functions to maintain the homeostasis of blood calcium concentrations.
Hypocalcaemia can stimulate the secretion of parathyroid hormone from the
parathyroid gland. This hormone along with vitamin D3 maintains calcium
homeostasis.
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