Microgenics Magnesium - Chelated Magnesium 500mg

MICROgenics Chelated Magnesium 500mg

Why should I take MICROgenics¨ Chelated Magnesium 500mg?

• Nervous tension, mild anxiety, stress
• Muscle tension, weakness, spasms, cramps
• Restless legs
• Pre-menstrual symptoms

Benefits of MICROgenics Chelated Magnesium 500mg:

MICROgenics¨ Chelated Magnesium 500mg can be used to help relieve muscle cramps and spasms, nervous tension, stress, mild anxiety, sleeplessness, and improve general wellbeing.

Product Features:

• High potency magnesium, 100mg of elemental magnesium per tablet.
• Magnesium as amino acid chelate, an easily absorbed form.
• Magnesium is vital for nerves, muscles, and bones.
• Insufficient magnesium can lead to overactivity of the nervous system and cause anxiety, stress, and nervous tension.
• Magnesium helps relieve nervous symptoms associated with pre-menstrual syndrome.
• Magnesium helps relax muscles and relieves muscle tension, spasms, restless legs, and cramps.

Dosage for MICROgenics Chelated Magnesium 500mg:

Adults: Take four tablets daily or as directed by your healthcare professional. Children 2-8 yrs: Take one tablet daily. Children 9-12 yrs: Take two tablets daily. Not recommended for children under 2 yrs of age.

No added:

Yeast, gluten, lactose, sugar, artificial colours or flavours, artificial sweeteners or preservatives, dairy products or animal derived products.

MICROgenics Chelated Magnesium 500mg Ingredients (per vegicap):

Warnings: High doses may have a mild laxative effect.

Magnesium is important for nerves, muscles, and bones

Magnesium is an essential dietary mineral mainly found in bone (53% of total body magnesium), muscle (27%), and soft tissue (19%).1 It is a co-factor for more than 300 enzyme systems and functions as a calcium antagonist inside cells. It has a structural role in bones, cell membranes, and chromosomes. It complexes with adenosine triphosphate (ATP), the body’s energy store in cells, and is a cofactor for cholesterol-regulating enzymes and the formation of glutathione, an important antioxidant. It helps prevent toxicity of the heart drug, digitalis. Magnesium has an important role in bone metabolism, immunity, hormone metabolism, calcium metabolism, transport across cell membranes, muscle contraction, tone of blood vessels, cardiac function, and nerve cell activity.1,2

Magnesium relieves stress, nervous tension and mild anxiety

Magnesium deficiency causes nervous hyperexcitability, muscle spasms and convulsions and is associated with hyperventilation syndrome, chronic fatigue syndrome, and neurocirculatory asthenia (a psychosomatic disorder induced by stress and characterised by anxiety, shortness of breath, heart palpitations, rapid pulse, giddiness, vertigo, tremors, chest pain, and fatigue).3 Magnesium stores are depleted by stress which causes magnesium to move from the interior to the exterior of cells, increasing urinary excretion,4 and this depletion is associated with increased anxiety.5

Magnesium relieves muscle cramps

About one in two elderly people suffer recurring cramps in the limbs while at rest.6 Case reports indicate that magnesium deficiency can cause weakness in the legs, generalised muscle tenderness and aching, severe, acute muscle spasms, and severe abdominal cramps that are poorly controlled by analgesics.7 In a magnesium deficiency, nerves impulses are generated more quickly and more calcium is released during muscle contractions, causing hyperactivity of nerves and muscles and twitches, spasms, and cramps.8

A Cochrane systematic review found that magnesium is a promising treatment for relieving painful menstrual cramps9 and another Cochrane review found that, although the trials reviewed were not of high quality, there was evidence that magnesium may help relieve leg cramps in pregnancy.10 A trial of magnesium for chronic nocturnal leg cramps, 300 mg a day for six weeks, found a trend towards fewer cramps and significantly more of those taking magnesium reported benefits compared to those on placebo.11

Magnesium may relieve restless legs syndrome

Restless legs syndrome (RLS) is a condition causing an uncomfortable, restless feeling in the legs accompanied by the urge to move them, usually occurring at rest and worsening in the evening and at night. Symptoms are relieved by movement. RLS can be associated with periodic limb movements (PLMS), involuntary contractions of the legs during sleep that contribute to insomnia. RLS may be associated with genetic factors, pregnancy, and iron, magnesium, vitamin B12 or folate deficiency.12

Subjects with RLS and magnesium deficiency have been found to have hyperactivity of nerves and muscles.13 A small study using magnesium supplementation in patients with mild or moderate insomnia related to RLS or PLMS found that it decreased the frequency of symptoms and improved sleep quality.14

Magnesium is important for exercise performance

Physical exercise may deplete magnesium, and inadequate magnesium levels may impair energy metabolism, muscle function, oxygen uptake, and electrolyte balance.15 Marginal magnesium deficiency impairs exercise performance and increases oxidative stress. It is estimated that magnesium requirements are increased by 10-20% by strenuous exercise because of increased urinary and sweat losses and a magnesium intake less than 260 mg a day for male athletes and 220 mg a day for females may result in magnesium depletion.16

Magnesium can relieve symptoms of premenstrual syndrome (PMS)

PMS symptoms usually begin in the last ten days of the menstrual cycle when progesterone levels drop and, although the causes are not clear, may be due to overproduction of inflammatory substances, an imbalance between oestrogen and progesterone, or an extra sensitivity to normal hormonal changes. Common PMS symptoms include anxiety, irritability, nervous tension, mood swings, fatigue, abdominal bloating, and fluid retention.

Oral magnesium (360 mg a day) was found to help relieve mood changes in women with PMS17 and 200 mg of magnesium with 50 mg of vitamin B6 daily was able to reduce symptoms of nervous tension, mood swings, irritability, or anxiety.18 A study that used 200 mg of supplementary magnesium for two menstrual cycles found fluid retention was reduced in the second cycle.19

Magnesium helps maintain bone mineral density

Animal studies show that magnesium deficiency results in bone loss, possibly caused by release of inflammatory chemicals and impaired production of parathyroid hormone and active vitamin D.20 Higher magnesium intake has been associated with greater bone mineral density in elderly people.21 Serum magnesium was found to be significantly lower in women with osteoporosis than in both women with low bone density and normal women.22 Magnesium supplementation was associated with reduced bone turnover in healthy young men23 and oral magnesium given for one year was able to improve bone mass in postmenopausal women with osteoporosis.24

References:

1. Fawcett WJ, Haxby EJ, Male DA. Magnesium: physiology and pharmacology. Br J Anaesth. 1999 Aug;83(2):302-20.
2. Abbott LG, Rude RK. Clinical manifestations of magnesium deficiency. Miner-Electrolyte-Metab. 1993; 19(4-5): 314-22.
3. Durlach J, Bac P, Durlach V, et al. Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance. Magnes Res. 1997 Jun;10(2):169-95.
4. Galland L. Magnesium, stress and neuropsychiatric disorders. Magnes Trace Elem. 1991-1992;10(2-4):287-301.
5. Grases G, PŽrez-Castell— JA, Sanchis P, et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes Res. 2006 Jun;19(2):102-6.
6. Butler JV, Mulkerrin EC, O’Keeffe ST. Nocturnal leg cramps in older people. Postgrad. Med. J. 2002;78:596-598.
7. Bilbey DL, Prabhakaran VM. Muscle cramps and magnesium deficiency: case reports. Can Fam Physician. 1996 Jul;42:1348-51.
8. Johnson S . The multifaceted and widespread pathology of magnesium deficiency. Med Hypoth. 2001;56(2):163-170.
9. Proctor ML, Murphy PA. Herbal dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev. 2002;(2).
10. Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2002;(1).
11. Roffe C, Sills S, Crome P, Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 2002 May;8(5):CR326-30.
12. Evidente V. The treatment and management of restless legs syndrome. Medscape Neurol & Neurosurg. 2006. 8(1).
13. Popoviciu L, et al. Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency. Rom J Neurol Psychiatry. 1993 Jan-Mar;31(1):55-61.
14. Hornyak M, et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 1998 Aug 1;21(5):501-5.
15. Laires MJ, Monteiro C. Exercise, magnesium and immune function. Magnes Res. 2008 Jun;21(2):92-6.
16. Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Magnes Res. 2006 Sep;19(3):180-9.
17. Facchinetti F, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991 Aug;78(2):177-81.
18. De Souza MC, et al. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med. 2000 Mar;9(2):131-9.
19. Walker AF, et al. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health. 1998 Nov;7(9):1157-65.
20. Rude RK, Gruber HE. Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem. 2004 Dec;15(12):710-6.
21. Tucker KL, Hannan MT, Chen H, et al. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 1999;69:727Ð36.
22. Mutlu M, et al. Magnesium, zinc and copper status in osteoporotic, osteopenic and normal post-menopausal women. J Int Med Res. 2007 Sep-Oct;35(5):692-5.
23. Dimai HP, et al. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8.
24. Stendig-Lindberg G, Tepper R, Leichter I. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res 1993;6:155Ð 63.