Orthoplex Chelatox
Dosage
1 tablet daily, or as prescribed
Indications
May be beneficial for:
• Supporting antioxidant defences
• Supporting immune function
Interactions
Chelatox should not be taken within two hours of antibiotic
medications as zinc and magnesium may reduce absorption
of antibiotics.
Contraindications
May stimulate detoxification, and therefore should not be
used during pregnancy or lactation.
Formulations
Glutamine 50mg
Cysteine 50mg
Grape seed extract equiv. dry 1g
Pine bark extract equiv. dry 600mg
Parsley equiv. dry 60mg
Bilberry equiv. dry 60mg
Garlic equiv. fresh bulb 60mg
Biotin 100μg
Ascorbic acid 60mg
Hesperidin 50mg
d-alpha tocopherol succinate 20mg (24.2IU)
Selenium (as selenomethionine) 25μg
Zinc (as amino acid chelate) 2mg
Magnesium (as orotate) 10mg
Broccoli sprout extract equiv. dry 500mg
TECHNICAL INFORMATION
Orthoplex Chelatox contains a number of herbs and
nutrients with specific actions, to provide antioxidant
support, immune support as well as specific support
for chelation and detoxification strategies.
Phase I and Phase II Detoxification
Cysteine
Cysteine is extremely helpful for liver and detoxification support
as it is an antioxidant in its own right, and also a precursor to
the endogenous antioxidant glutathione. Taurine can also be
manufactured from cysteine.
Cysteine has been described as having a pivotal role in inducible,
endogenous detoxification mechanisms in the body.[1] As such,
it is a precursor nutrient (with glutamine and vitamin C) to the
endogenous antioxidant and detoxification enzyme glutathione.
As mentioned above, glutathione is important as an antioxidant
to protect against free radical damage induced through phase I
liver detoxification and also as a phase II enzyme.
Broccoli sprouts
Edible plants belonging to the family Cruciferae and genus
Brassica (e.g. broccoli and cauliflower) contain substantial
quantities of isothiocyanates (mostly in the form of their
glucosinolate precursors) some of which (e.g. sulforaphane
or 4-methylsulfinylbutyl isothiocyanate) are very potent
inducers of phase II enzymes.[2] Some isothiocyanates have
been shown to inhibit cytochrome P450 and increase the
carcinogen excretion or detoxification by the phase II
detoxification enzymes.[3] Sulforaphane, derived from
cruciferous vegetables, is the most potent known inducer of
phase II enzymes involved in the detoxification of xenobiotics.[4] Extracts of broccoli sprouts contain 10 – 100 times the phase II
inducer activity of mature broccoli plants.[5]
Grape Seed Extract
Grape seed proanthocyanidins in particular have been
shown to have significantly greater free radical scavenging
ability than vitamins C, E and beta carotene. Grape seed
proanthocyanidins may protect multiple target organs
from chemical induced toxicity.[6]
Heavy Metal Chelation
Chelation
Mercury, cadmium and lead can all be conjugated and excreted
with the assistance of glutathione.
Cysteine is also required for the activity of metallothionein, a
protein that binds metals. Metallothionein, in animal studies,
has been shown to be effective in binding cadmium specifically.[7]
Selenium
Selenium may bind and excrete several heavy metals
including arsenic, cadmium and both inorganic and methyl
forms of mercury.[8, 9]
Chlorella
Recent studies suggest that Chlorella may be capable of
dislodging and removing accumulated Dioxin from the body.
Several animal studies show results that indicate a potential
role for chlorella in the detoxification of dioxins. These studies
show Chlorella to inhibit the GI absorption of dioxins and also
promote the excretion of dioxin that has already been absorbed
into the tissues.[10-12] Authors claim these results suggest a useful
role for chlorella in humans.[10] A 2005 published study from Japan
indicates that chlorella supplementation may help to reduce the
maternal transfer of dioxins.[13] Few studies also suggest chlorella
to have immune enhancing effects.[14]
Garlic
A protective effect against heavy metal toxicity has been
observed when garlic is co-administered with cadmium or
mercury in animals. Decreased accumulation of the metals
was seen in the liver, kidneys and bones.[15]
Vitamin C
As well as being a powerful antioxidant, vitamin C may protect
against the toxic effects of heavy metals such as alumiunium,
lead and cadmium.[16] It has also been stated to facilitate the
removal of aluminium from the body.[17]
References
1. Ottenwalder, H., Simon, P., Differential effect of N-acetylcysteine on excretion of the metals Hg, Cd, Pb and Au. Arch Toxicology, 1987. 60(5): p. 401-2.
2. Fahey, J., Zhang, Y., Talalay, P., Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
Proc Natl Acad Sci, 1997. 94: p. 10367-10372.
3. Morimitsu, Y., et al., A Sulforaphane Analogue that Potently Activates the Nrf2-dependent Detoxification Pathway.
The Journal of Biological Chemistry, 2002. 277(5): p. 3456-3463.
4. Ritz, S., Wan, J., Diaz-Sanchez, D., Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells
stimulated with diesel extract. Am J Physiol Lung Cell Mol Physiol, 2007. 292: p. L33-L39.
5. Nestle, M., Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: Clinical, dietary and policy implications.
Proc Natl Acad Sci, 1997. 94: p. 11149-11151.
6. Bagchi, D., et al., Cellular protection with proanthocyanidins derived from grape seeds. Ann NY Acad Sci, 2002. 957: p. 260-70.
7. Park, J., Liu, Y., Klaassen, CD., Protective effect of metallothionein against the toxicity of cadmium and other metals.
Toxicology, 2001. 163(2-3): p. 93-100.
8. Reilly, C., Selenium in Food and Health. 1996, London, UK.: Blackie Academic and Professional.
9. Rayman, M., The importance of Selenium to human health. Lancet, 2000. 356(9225): p. 233-241.
10. Morita, K., Matsueda, T., Lida, T., Hasegawa, T., Chlorella accelerates dioxin excretion in rats. J Nutr., 1999. 129(9): p. 1731-6.
11. Takekoshi, H., Suzuki, G., Chubachi, H., Nakano, M., Effect of Chlorella pyrenoidosa on fecal excretion and liver accumulation of polychlorinated
dibenzo-p-dioxin in mice. Chemosphere., 2005. 59(2): p. 297-304.
12. Morita, K., Ogata, M., Hasegawa, T., Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates
dioxin excretion in rats. Environ Health Perspect., 2001. 109(3): p. 289-94.
13. Nakano, S., Noguchi, T., Takekoshi, H., Suzuki, G., Nakano, M., Maternal-foetal distribution and transfer of dioxins in pregnant women in Japan,
and attempts to reduce maternal transfer with Chlorella (Clorella pyrenoidosa) supplements. Chemosphere., 2005. 61(9): p. 1244-55.
14. Merchant, R., Andre, CA., A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyaliga,
hypertension and ulcerative colitis. Altern Ther Health Med., 2001. 7(3): p. 79-91.
15. Cha, C., A study on the effect of garlic to the heavy metal poisoning of rat. J Korean Med Sci., 1987. 2(4): p. 213-24.
16. Hsu, P., Guo, YL., Antioxidant nutrients and lead toxicity. Toxicology, 2002. 180(1): p. 33-44.
17. Fulton, B., et al., Absorption and retention of aluminium from drinking water. Effect of citric and ascorbic acids on aluminium tissue levels in rabbits.
Fundam Appl Toxicol. 14(4): p. 788.
