Orthoplex H.G.F.

Orthoplex H.G.F.

Excipients

Dosage

1 tablet after each meal, or as prescribed.

Orthoplex H.G.F. Indications

May help to maintain:
* Healthy blood sugar levels
* Energy production
* Protein and fat digestion

Interactions

Should not be taken within two hours of antibiotic medications, as calcium, zinc, magnesium and manganese may reduce absorption of antibiotics.
May potentiate the effects of hypoglycaemic medications.

Each tablet of Orthoplex H.G.F. contains:

Blood sugar Irregularities
Chromium is an essential component of Glucose Tolerance Factor (GTF), a substance known to improve glucose tolerance by potentiating the effect of insulin on carbohydrate metabolism.[3] Chromium supplementation may improve glucose uptake in insulin sensitive tissues. Chromium supplementation may also help to prevent the development of atherosclerosis, and lower LDL levels.[4] Deficiency of chromium is associated with fatigue, glucose intolerance, growth impairment and hypercholesterolemia.[5, 6]

Chromium improves the glucose/insulin system in subjects with hypoglycemia, hyperglycemia, diabetes and hyperlipidemia.[7] Chromium improves insulin binding, insulin receptor numbers, insulin internalization, beta cell sensitivity and insulin receptor enzymes with overall increase in insulin sensitivity.

Energy production
In glucose metabolism, there are two major processes involved; an anaerobic phase (glycolysis) and an aerobic phase (Krebs or Citric acid cycle). The two cycles work in combination to produce energy (ATP).

Magnesium (Mg++), manganese (Mn++), potassium (K+), iron (Fe++), cobalt (Co++) zinc (Zn++), lipoic acid and vitamins B5, B1, B2, B3 assist the enzymes to produce ATP.

Also of importance is the presence of the substance nicotinamide adenine dinucleotide (NADH). This cofactor is one of two main substrates for conversion through to ATP. Vitamin B3 (Niacin) makes up part of this NADH.

Dyslipidemia
Chromium deficiency is associated with altered blood lipid levels, namely hyperlipidemia. In a double blind cross over study, 28 volunteer subjects were given either chromium tripicolinate (200 micrograms chromium) or a placebo daily for 42 days. Levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, and apolipoprotein B, the principal protein of the LDL fraction, decreased significantly while the subjects were ingesting chromium picolinate. The concentration of apolipoprotein A-I, the principal protein of the high-density lipoprotein (HDL) fraction, increased substantially during treatment with chromium picolinate. The HDL-cholesterol level was elevated slightly but not significantly during ingestion of chromium picolinate. Of the variables measured, only apolipoprotein B was altered significantly during supplementation with the placebo. These observations show that chromium picolinate is efficacious in lowering blood lipids in humans.

Protein & Fat Metabolism
Fats and amino acids also enter the energy cycle. Whereas fats only enter via the AcetylCoA part of the cycle, amino acids can enter through a number of different points throughout theCtric acid cycle. Once again a vitamin based cofactor is involved-vitamin B6 (pyridoxine). Vitamin B6 in its active form, pyridoxal 5-phosphate, helps convert the amino acids to the appropriate metabolites for entry into the Kreb's cycle.

Together with the minerals previously mentioned and also the important nutrients involved in the formation and action of insulin, conversion of food through to utilizable energy is completed.