Orthoplex Inhibin 2
For the symptomatic relief of anxiety.
Contains histidine, which is involved in the production of histamine, a
neurotransmitter.
Contains serine and threonine, precursors to glycine.
Contains threonine and glycine, which may assist is supporting muscle tremors.
The active ingredients in Orthoplex Inhibin 2, when appropriately prescribed,
may assist patients suffering from the above conditions. This statement does not
imply or make a claim for a cure of these disorders. The use of Orthoplex Inhibin 2 should be based on the published and relevant scientific and clinical
data for each condition.
Excipients
Calcium hydrogen phosphate, povidone, crospovidone, microcrystalline
cellulose, magnesium stearate, hypromellose, macrogol 400, tartaric acid.
Synergistic Formulae
DHA/EPA
Cautions and Contraindications
Caution with anti-histamine medications such as Actifed, Avid, Claratyne,
Demazin, Zyrtec, Sudafed, Telfast. Caution in people who may have high histamine
levels. May potentially exacerbate seasonal allergies, though uncommon.
Dosage
1 tablet three times daily one hour before meals or as prescribed.
Each tablet contains:
|
Calcium ascorbate |
75 mg |
|
Folic acid |
150 µg |
|
Glycine |
50 mg |
|
Histidine hydrochloride |
200 mg |
|
Magnesium oxide |
50 mg |
|
(equiv. magnesium 30 mg) |
|
|
Nicotinamide (vitamin B3) |
10 mg |
|
Pyridoxine hydrochloride (vitamin B6) |
5 mg |
|
Serine |
50 mg |
|
Threonine |
150 mg |
|
Zinc amino acid chelate |
10 mg |
|
(equiv. zinc 2 mg) |
|
TECHNICAL INFORMATION
Histidine is the amino acid precursor to the inhibitory neurotransmitter,
histamine. This neurotransmitter is mainly concentrated in the pituitary and
hypothalamic neurons. It promotes alpha wave activity in the brain and hence
improves resistance to stress and anxiety. A histamine imbalance results in
psychological disorders such as anxiety and schizophrenia as well as lethargy,
fatigue, poor appetite and nausea.
Anxiety
Histamine is involved in many central nervous system functions such as arousal,
alertness, activation of the sympathetic nervous system, the stress-related
release of hormones from the pituitary and of central aminergic
neurotransmitters, anti-nociception, water retention and suppression of eating.
Memory Loss
Recent studies indicate that the histaminergic system, which is critical for
wakefulness, also influences learning and memory by interacting with cholinergic
systems in the brain. An indirect mechanism involving local acetylcholine
release has been highlighted in the histaminergic modulation of memory and
learning.[15]
Hypochlorhydria
Histamine is involved in the secretion of gastric acid in the stomach and H2
receptor antagonists have long been used to inhibit gastric acid production.[16]
Histamine deficiency may therefore be involved in under-production of gastric
acid. A recent study has suggested that a lack of histamine may also alter
gastric mucosal morphology.[17]
Copper Chelation
Histidine is a powerful metal chelator, and specifically chelates copper. Copper
excess has been implicated in conditions such as Alzheimer's disease[18] and
Rheumatoid arthritis.
Histapenic schizophrenia
Both high and low levels of histamine have been associated with different
diagnoses of schizophrenia.[10] Low histamine is associated with positive
symptoms such as hallucinations, paranoia, delusions and disorganised behaviour.
Histamine receptor agonist drugs have been used in the treatment of histapenic
type schizophrenia.
Convulsions
Studies examining the effects of low histamine on seizure development, and
the ability of histidine to enhance anticonvulsant medication have concluded
that histidine might serve as a beneficial adjuvant for the clinical treatment
of epilepsy, especially when accompanied by impaired spatial memory. Specific
histaminergic modulation of neuronal activity in the amygdala may play an
important role in amygdala-mediated physiological and pathophysiological
processes such as fear, emotional learning and memory, temporal lobe epilepsy
and affective disorders.
