Orthoplex L.M.1
Excipients
Calcium hydrogen phosphate, povidone, crospovidone, silicon dioxide, magnesium
stearate, cellulose microcrystalline, hypromellose, macrogol 400.
Pack size
60 tablets.
Dosage
2 tablets morning and night, or as prescribed.
Indications
May help to support healthy liver detoxification processes.
Interactions
Contains ingredients which may support elimination, therefore do not take within
2-4 hours of other medications.
Should not be taken within two hours of antibiotic
medications, as calcium, zinc, magnesium and manganese may reduce absorption of
antibiotics.
Contraindications
N/A
Each tablet of Orthoplex L.M.1 contains:
|
Betaine (TMG) |
50 mg |
|
Choline bitartrate |
200 mg |
|
Cyanocobalamin (vitamin B12) |
100 µg |
|
dl-methionine |
100 mg |
|
Folic acid |
100 µg |
|
Glutamic acid |
100 mg |
|
Inositol |
150 mg |
|
Magnesium oxide |
100 mg |
|
(equiv. magnesium 60 mg) |
|
|
Potassium sulphate |
60 mg |
|
(equiv. potassium 26.9 mg) |
|
|
Pyridoxine hydrochloride (vitamin B6) |
10 mg |
|
Taurine |
125 mg |
TECHNICAL INFORMATION
Liver detoxification
Choline, methionine and inositol are generally known as lipotropic factors or
liver metabolites. They can prevent the build up and deposition of fat in the
liver. The liver plays a central role in many metabolic pathways, so any general
interference with liver function can have extremely diverse effects. For
example, impaired liver function may lead to dysfunction in uric acid
metabolism, and hence to gout or problems in maintaining circulation. Altered
protein synthesis, growth and development, and even problems in kidney function
may also result.
The nutrient combination in LM1 is specific to support
phase II liver detoxification pathways.
Sulfation
Methionine
Methionine as a lipotrope is ultimately involved with lipid metabolism in the
liver. Deficiencies of protein, methionine and choline have been implicated in
liver injury. Methionine has primarily a protective role in prevention of fatty
accumulation caused by chronic alcohol consumption, high blood lipids or intake
of toxic substances. Methionine exerts its enhancement of the phase II
conjugation pathway of sulfation, via its ability to act as a source of
sulfhydryl (SH) groups which bind to toxic agents (usually free radicals). This
also prevents damage to hepatocyte SH groups, which if oxidized lead to liver
damage.
Taurine
Taurine is a sulphur-containing amino acid known for its involvement in the
formation of taurocholic acid, a component of bile. Basically taurine's function
is to facilitate the passage of sodium, potassium and possibly calcium and
magnesium ions into and out of cells, and thus electrically stabilise the cell
membrane. Taurine is involved in the conjugation and excretion of toxins through
the bile and helps the liver excrete excess cholesterol through the bile.
Potassium Sulfate
Potassium sulfate provides a form of inorganic sulfur which can be used in
sulfate conjugation.
Methylation
Methionine, vitamin B12, folic acid, choline
In combination with vitamin B12 and folic acid, methionine
is involved in methylation reactions with choline. These methylation reactions
are important not only for detoxification reactions, but also for the production
of noradrenaline and in regulating the cell cycle. It has been shown that in
many cancers the DNA is under-methylated.
Methylation involves the conjugation of a methyl group
with a substrate. Methionine and the cofactors choline, vitamin B12 and folic
acid are involved in the synthesis of SAMe (s-adenosylmethionine), the major
methyl donor in the body. Although this pathway is not directly assessed in a
functional liver detoxification profile, it may be possible to measure serum
homocysteine, vitamin B12 and folic acid levels. High homocysteine, low B12 and
folic acid may indicate a decrease in methylation.
Pyridoxine (B6) and cyanocobalamin (B12) act as cofactors
in the methionine transsulfuration pathway. Availability of these substrates and
cofactors is essential to maintain adequate levels of methionine and choline
which act as key lipotropic agents and the major methylating agents used in the
body for the production of hormones, neurotransmitters, detoxification reactions
and regulation of cell division.
Glutathionation
Glutathione conjugation binds toxins such as heavy metals, pesticides and
solvents and transforms them into a soluble form that can be excreted in the
urine or bile. High level toxin exposure depletes glutathione faster than it can
be produced or absorbed leading to increased susceptibility to diseases
associated with elevated toxins such as cancer, chronic fatigue syndrome and
auto-immune diseases.
Glutamic acid
Glutamic acid facilitates the production of the glutathione peroxidase enzyme.
Glutamic acid's role in liver function is primarily a protective one, involved
with the detoxification of ammonia. The synthesis of urea by the liver is the
major mechanism for the removal of ammonia, but if liver function is impaired,
urea synthesis may not be sufficient and blood ammonia levels rise.
