Orthoplex Lymphodran Plus
Excipients
Povidone, calcium hydrogen phosphate, crospovidone, silicon dioxide, cellulose
microcrystalline, magnesium stearate, hypromellose, macrogol 400, carnauba wax.
Pack size
60 tablets.
Dosage
1 tablet of Orthoplex Lymphodran Plus three times daily, or as prescribed.
Indications
May be beneficial for conditions associated with:
* Inflammation
* Wound healing
* Viral infections
* Oedema
Interactions
N/A.
Contraindications
N/A
Each tablet of Orthoplex Lymphodran Plus contains:
|
Ascorbic acid (vitamin C) |
50 mg |
|
Bromelain |
100 mg |
|
(2400 GDU) |
|
|
Quercetin |
500 mg |
|
Rutin |
400 mg |
TECHNICAL INFORMATION
Inflammation, oxidative stress and immune dysfunction underlie many health
disorders and disease states. It is fundamental to address these processes in
order to maximise your patient's health potential. Studies have supported the
use of quercetin, bromelain and rutin to down regulate inflammation, reduce
oxidative stress, modulate viral activity and to support immune health and wound
healing processes.
Inflammation
Many substances have been researched for their anti-inflammatory effect; one of
the most potent of the natural substances is quercetin. Quercetin down regulates
a number of inflammatory mediators including Cyclooxygenase[3] and
Lipoxygenase[4] pathways; NF-kappa B;[5] Tumour Necrosis Factor alpha;[6]
Prostaglandin E2;[7] Series 4 Leukotrienes[8] and Histamine.[9]
Like quercetin, rutin has shown to help support
inflammatory processes. It has been suggested that rutin may play a more
specific role in chronic inflammatory processes.[10]
Bromelain can help to reduce oedema and inflammation. In
vivo and in vitro studies have suggested that bromelain has the ability to
reduce inflammatory mediators such as prostaglandin E2 and substance P.[11]
Bromelain has also been shown to reduce bradykinin which is involved in pain and
inflammation.[12]
Wound healing
Bromelain may play an important role in wound healing; it has been shown to
improve healing time following trauma and surgical procedures.[2] It has been
suggested that a non-proteolytic component of bromelain is involved in the wound
healing properties of the nutrient.
Oedema
Studies dating back to the 1960's have been conducted on the potential of
flavonoids to act as capillary stabilizers. A recent animal study in 2003 found
that a flavonoid compound could completely abolish arachidonate induced vascular
permeability.[16] A Cochrane review in 2000 found that rutosides (a flavonoid
compound) appeared to relieve symptoms of venous insufficiency in late
pregnancy, although safety was not confirmed during pregnancy.[17]
Oxidative Stress
Rutin possesses antioxidant properties and may help to support immune health. In
animal studies rutin has been shown to increase total superoxide dismutase (an
antioxidant enzyme) activity in the liver.[18]
Quercetin has been shown to inhibit LDL oxidation in vitro
and protect against oxidative damage in a number of health conditions. For
example, quercetin has been shown to protect neurovasculature structures in skin
from oxidative damage.[
Viral Infections
In vitro studies show quercetin possesses antiviral properties. A study
conducted on Herpes simplex type 1, polio-virus type 1, parainfluenza virus type
3 (Pf-3), and respiratory syncytial virus (RSV) found that quercetin caused a
concentration-dependent reduction in the infectivity of each virus. In addition,
it reduced intracellular replication of each virus.[13]
Apoptosis
Quercetin has also been shown to upregulate apoptosis (healthy programmed cell
death) and down regulate mitosis (cell division) thus having a direct effect on
cancer cell growth and development. Due to its ability to upregulate apoptosis,
quercetin has also shown promising benefit as support therapy during
chemotherapy.
