Orthoplex MagOpticell #1453270964

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Orthoplex MagOpticell

Excipients
Malic acid, Stevia rebaudiana leaf extract dry, trusil fruit punch flavour, tropical fruit flavour.

Dosage of Orthoplex MagOpticell
6.5g (approx. 1¾ level 5mL metric spoonful) daily in water, or as prescribed. Recommended to be taken with food.

Indications
May be beneficial for the following:
* Nervous tension, stress, anxiety
* Relief of muscular cramps and spasms
* Cardiovascular health
* Mitochondrial energy production
* Temporary relief of migraine headache

Interactions
Should not be taken within two hours of antibiotic medications, as calcium, zinc, magnesium and manganese may reduce absorption of antibiotics.[19,20]

Contraindications
Use magnesium with caution in people with renal failure. High doses of creatine are contraindicated in kidney failure.

TECHNICAL INFORMATION
Magnesium is the fourth most abundant mineral in the body and plays a crucial role in biochemistry, being involved in over 300 metabolic reactions.[5]

Nervous tension, Stress and Anxiety
Magnesium deficiency can present with nervous system dysfunction including stress, aggressiveness,[6] anxiety,[7] poor concentration, headaches[8] and even depression.[9]

Magnesium supplementation to correct magnesium deficiency may therefore alleviate nervous tension, stress, anxiety and depression. Magnesium supplementation has also been found beneficial in the support of epilepsy sufferers.[10]

The B vitamins are required for optimal nervous system functioning. They may complement magnesium supplementation in supporting the nervous system and adrenal glands.

Muscle Cramps and Spasms
Magnesium concentrates in the muscles and is required for ATP production and the transmission of nerve impulses to the muscles. Magnesium deficiency has been associated with muscle cramps, low bone mineral density, reduced muscle strength, muscle weakness and fatigue.

A randomised, double blind, placebo controlled crossover pilot study showed malic acid in combination with magnesium to reduce muscle pain and tenderness in fibromyalgia patients.[11]

Oral supplementation of creatine increases muscle supply of free creatine and creatine phosphate, a high-energy phosphagen. Creatine levels have been found to be low in those suffering from fibromyalgia.[12]

Cardiovascular health
Magnesium deficiency may contribute to cardiovascular dysfunction such as hypertension and coronary artery disease. Clinical evidence has suggested that magnesium influences vascular tone and may play an important role in regulating blood pressure by having a direct effect upon the relaxation capability of vascular smooth muscle cells.[13]

As potassium plays an essential role in the membrane potential of cardiac muscle, it may help to regulate the contraction of the cardiac muscle. Low potassium levels may lead to alterations in cardiac rate, rhythm and conduction.[14] A randomised, placebo controlled trial showed that supplementation of potassium in 150 men and women with high blood pressure resulted in a substantial reduction in systolic blood pressure.

Mitochondrial Energy Production
Magnesium is required for energy production and ATP exists in many cells as an ATP-Mg complex. Creatine is an endogenous amino acid, which concentrates in the skeletal muscles and improves the condition of muscle fibres.[16] The creatine kinase system is involved in the rapid transport of high energy phosphates from the mitochondria to sites of maximal energy requirements such as myofibrils and sarcolemmal ion pumps.

Creatine may also improve muscle tone and lean muscle mass in weight training individuals.

Malic acid is an intermediate endogenous acid in the Krebs cycle, and is therefore involved in energy production. Supplementation of malic acid has been shown to enhance physical working capacity and stimulate productive bioenergetic processes.