Orthoplex S.F.M. Thyroid and Adrenal Support #1453270966

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Orthoplex S.F.M. Thyroid and Adrenal Support

Excipients
Calcium hydrogen phosphate, cellulose microcrystalline, povidone, silica colloidal anhydrous, crospovidone, magnesium stearate, opadry clear, vanillin, carnauba wax

Dosage
1 tablet of Orthoplex S.F.M. Thyroid and Adrenal Support twice daily, or as prescribed.

Indications
May help to support:
* Healthy thyroid function
* Healthy adrenal gland function
* The body during times of stress
* Nutrition, for healthy mood

Interactions
Other amino acids may compete with tyrosine for absorption, particularly large neutral amino acids and branch chain amino acids (e.g., tryptophan, phenylalanine, leucine, isoleucine and valine).
Use with caution with the following medications:
* Monoamine Oxidase Inhibitors
* Selective Serotonin Reuptake Inhibitors
* Tricyclic anti-depressants
* Thyroid medication
* ACE inhibitors
* L-Dopa or Carbidopa

Contraindications
Tyrosine should be avoided in people with hyperthyroid and Grave's disease.
Use tyrosine with caution in patients with hypertension.

Each tablet of Orthoplex S.F.M. Thyroid and Adrenal Support contains:
Ascorbic acid (vitamin C) 100mg
Calcium pantothenate (vitamin B5) 50mg
Chromium nicotinate 15µg
Iodine (as potassium iodide) 100µg
Nicotinamide (vitamin B3) 40mg
Nicotinic acid (vitamin B3) 10mg
Pyridoxine hydrochloride (vitamin B6) 25mg
Rehmannia 400mg
Riboflavin 5-phosphate (vitamin B2) 10mg
Selenium (as selenomethionine) 50µg
Thiamine hydrochloride (vitamin B1) 10mg
Tyrosine 500mg
Withania 300mg
Zinc citrate 4mg

TECHNICAL INFORMATION
Thyroid Hormone Synthesis
The thyroid gland plays a major role in metabolism. Dysfunction of the thyroid gland, such as hypothyroidism or hyperthyroidism, can slow or speed up metabolism respectively. The synthesis of the major metabolites of the thyroid gland; Thyroxine (T4), Triodothyronine (T3) and Reverse T3 (rT3), is dependent on the availability of certain nutrients. Tyrosine and Iodine are the most important of these, being the precursors for thyroid hormone production. Co-factor nutrients including copper, zinc, chromium, vitamin C and selenium are also important for thyroid function. Deficiencies of these nutrients have been shown to decrease thyroid function.(1)

Weight Management
T3 and T4 are important hormones in relation to fat metabolism. Starvation diets not only decrease the amount T3 and T4 in the circulation, but also contribute to blood sugar fluctuations which may affect eating habits and increase lipogenesis. (2) T3 and T4 increase the body's basal metabolic rate and have been found to increase weight loss in people with metabolic imbalance. (3)
In addition to the importance of tyrosine in thyroid hormone production, tyrosine is also required for catecholamine (including norepinephrine) synthesis.(4) The cofactors involved with norepinephrine synthesis must also be considered, including vitamin C, zinc, vitamin B5 and vitamin B2. Supporting the synthesis of norepinephrine has been found to increase thermogenesis of brown fat cells, thus increasing fat utilization.(5)
Blood sugar irregularities
Studies have shown that obese people are more prone to abnormalities with glucose metabolism. Some obese people show poor results from a 5 hour Glucose Tolerance Test, and may have raised circulating levels of insulin. Insulin is a 'clearance hormone, as it removes glucose from the blood into the cells and fat stores, thus slowing the rate of fat catabolism into energy. In some obese people, chromium has been shown to improve the glucose tolerance by lowering the glucose peaks and the amounts of circulating insulin.(6)

Adrenal support
As discussed, the nutrients tyrosine, vitamin C, zinc, vitamin B5 and vitamin B2 are essential for the production of adrenal hormones. Herbal support may also be utilized to promote adrenal health and function.
Rehmannia may be considered as an adrenal tonic due to its regulatory activity on the hypothalamic-pituitary-axis (6) and due to an inhibitory effect on the breakdown of corticosteroids systemically, (7) which alleviates demand for excessive adrenal production of these hormones.

Stress
Withania has been reported to have anxiolytic properties,(8) and may be a valuable herb for use during periods of stress due to agonist activity at GABA receptors. (9) Chronic periods of stress may lead to depletion of hormones produced by the adrenal medulla including noradrenaline and adrenaline. Precursor nutrients, such as tyrosine may be used to improve production of these hormones.

Memory
A decline in learning ability and memory may be caused by a number of factors. Nutrient deficiencies, particularly B vitamins may reduce brain function and therefore contribute to cognitive impairment. B vitamins of particular importance include B6, B12 and folic acid, as these reduce homocysteine levels, and high homocysteine may contribute to damage to brain tissue. (11)
Neurotransmitters within the brain are important in memory and mental function. Tyrosine may increase dopamine and noradrenaline levels which are neurotransmitters involved in cognitive function. Additional neurotransmitters involved in cognition include GABA which requires the nutritional precursors zinc and vitamin B6 for production, and acetylcholine which requires precursors including thiamine and pantothenic acid. Acetylcholine receptor activity has also been found to be improved with Withania supplementation, indicating the benefit of Withania for cognitive function.