Orthoplex Ultra Buffered C Powder #1453270967

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Orthoplex Ultra Buffered C Powder

Excipients
Trusil orange natural flavour, stevia rebaudiana leaf ext. dry conc., sodium bicarbonate, citric acid anhydrous, silica-colloidal anhydrous.

Dosage of Orthoplex Ultra Buffered C Powder
1 teaspoon per day, or as prescribed

Indications
May be beneficial for :
* Antioxidant properties
* Assisting in the maintenance of healthy immune function
* Helping to support connective tissue formation
* Assisting in the relief of cold symptoms
* Helping to support adrenal function

Interactions
Should not be taken within two hours of antibiotic medications, as zinc may reduce absorption of antibiotics.

Contraindications
Use with caution in people with haemochromatosis; vitamin C may increase the body's absorption of iron.

Each 5ml spoonful of Orthoplex Ultra Buffered C Powder contains:
Ascorbic acid (vitamin C) 1.56g
Betacarotene 4mg
Calcium ascorbate 500mg
(equiv. ascorbic acid 413.5mg)
d-alpha tocopheryl acid succinate (vitamin E) 68 mg
(equiv. vitamin E 100IU)
Hesperidin 100mg
Magnesium ascorbate 100mg
(equiv. ascorbic acid 93.52mg)
R,S alpha lipoic acid 50mg
Rutin 100mg
Sodium ascorbate 500mg
(equiv. ascorbic acid 441.96mg)
Zinc citrate 20mg
(equiv. zinc 6.42mg)

Buffered Vitamin C
Mineral ascorbates (which are also known as non-acid vitamin C) are buffered forms of vitamin C and are found to be less irritating to the gastrointestinal tract in some individuals than pure ascorbic acid. Sodium ascorbate and calcium ascorbate are the most common forms, although a number of other mineral ascorbates are available. Calcium ascorbate consists of 82% ascorbic acid bound to 18% calcium.

Oxidative stress
Vitamin C acts as an antioxidant and may reverse oxidation by donating electrons and hydrogen ions. Ascorbate may also donate electrons and hydrogen ions to regenerate vitamin E. Vitamin C may reduce reactive oxygen species such as hydroxyl radicals, hydroperoxyl radicals, superoxide radicals, alkoxyl radicals and peroxyl radicals. As a fat-soluble antioxidant, betacarotene may add additional antioxidant support by scavenging singlet oxygen[4] and decreasing lipid peroxidation.[5] As an immune modulator it has been found to increase CD4 counts, CD4/CD8 ratios, and total WBC counts.[6]
Alpha lipoic acid has been attributed with the action of regenerating and recycling other antioxidants to strengthen the antioxidant network in the body.

Immune function
The concentration of ascorbate in leucocytes is one of the highest known and is considered to be second only to that in the adrenals and pituitary glands.[1] A number of chronic diseases and conditions which lead to depressed immunity such as cancer,[7] diabetes,[8] ageing,[9] corticosteroid therapy and pregnancy are also associated with low levels of plasma and leucocyte vitamin C.
Ascorbate is necessary for protein synthesis and antibody formation and the maintenance of ascorbate concentrations at a high level in leucocytes helps attain the rapid oxidation/reduction activity required for overall synthesis of gamma globulins. Vitamin C also stimulates lymphocytes to transform into appropriate T and B blast cells, the precursors of the effector cell in both cell mediated and humoral immunity. In addition, the inhibition of the transformation by influenza virus is corrected by large doses of vitamin C.
Histamine is found within tissue mast cells or basophil leucocytes and is released in response to biochemical stress such as burns, infection, drugs, allergy and free radical induced membrane oxidative damage. Studies indicate that vitamin C may indirectly enhance chemotaxis by detoxifying histamine in vivo.[10]

Collagen production
Vitamin C has a critical role in the synthesis of collagen and mucopolysaccharides and subsequent cross-linking of the fibres to give new tissue strength to damaged tissue. It may therefore assist with wound healing and growth. Two hydroxylation reactions requiring vitamin C are necessary for collagen production - proline and lysine hydroxylation.[11] Ascorbate is required to reduce the iron co-factor back to its ferrous state in prolyl and lysyl hydroxylases.[1]
Rutin and bioflavonoids may also help support connective tissues, by limiting inflammation and tissue degradation and promoting a strong collagen matrix.